METABOLIC CONSEQUENCES OF METHIONINE REDOX IN METHIONINE RESTRICTION
نویسندگان
چکیده
منابع مشابه
Methionine restriction inhibits colon carcinogenesis.
Previously, we demonstrated that life-long methionine restriction (MR) in rats increases life span and inhibits aging-related disease processes. The present study examines the effects of MR on the formation of preneoplastic aberrant crypt foci (ACF) in the colon of azoxymethane (AOM)-treated rats. Six-week-old male F344 rats were placed on essential amino acid-defined diets containing either 0....
متن کاملPleiotropic responses to methionine restriction
Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in both organs during MR. In fat, MR induced a futile lipid cycle concomitant with...
متن کاملRedox proteomics of protein-bound methionine oxidation.
We here present a new method to measure the degree of protein-bound methionine sulfoxide formation at a proteome-wide scale. In human Jurkat cells that were stressed with hydrogen peroxide, over 2000 oxidation-sensitive methionines in more than 1600 different proteins were mapped and their extent of oxidation was quantified. Meta-analysis of the sequences surrounding the oxidized methionine res...
متن کاملBioavailability comparison between herbal methionine and DL-methionine on growth performance and immunocompetence basis in broiler chickens
BACKGROUND:Herbal methionine can be compared relative toDl-methionine with evaluation of bioavailability of this source ofmethionine. OBJECTIVES: An experiment was carried out todetermine the relative bioefficacy of herbal methionine (H-Met)®relative to DL-methionine (DL-Met) on performance criteria andimmunocompetence of Met sources in male broilers. Atotal of 160male broilers were fed a Met-d...
متن کاملConcentration-dependent Linkage of Dietary Methionine Restriction to the Components of Its Metabolic Phenotype
OBJECTIVE Restricting dietary methionine to 0.17% produces a series of physiological responses through coordinated transcriptional effects in liver and adipose tissue. The goal of the present work was to determine the threshold concentrations above and below 0.17% at which the beneficial responses to 0.17% dietary methionine are preserved. METHODS Diets were formulated to restrict methionine ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2019
ISSN: 2399-5300
DOI: 10.1093/geroni/igz038.398